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Unchanged Views of 472 SUNSET DR, Hallandale Beach Number 56. Folio Views 472 FULL 56 Views of 472 SUNSET DR, Hallandale Beach Number 56. Folio Views 472 FULL 56 Book View of 56 SUNSET DR, Hallandale Beach, 5.25 acres. 5 baths, 3 full, 2 half. Master suite downstairs. Mahogany floors. Large bedrooms with views of water and pool. Bath features spa tub, walk in shower with glass tub, double sinks, dual sinks, fire place. Newer windows. Custom closet and cabinetry. Retired owner.Cardiomyocyte-specific deletion of Abcb1a/b causes severe cardiac myopathy with prominent fibrosis. Aberrant glycosylation has been implicated in the pathogenesis of numerous human disorders. The export of a variety of substrates by the ABC transporters, which play key roles in the glucuronidation and excretion of drugs and metabolites, might also directly influence disease. Although mice with cardiovascular defects have been generated by knocking out Abcb1a/b (also called ABCB1), the precise functions of cardiac Abcb1a/b remain to be determined. In this study, we examined the physiological and pathological phenotypes of mice with cardiac-specific Abcb1a/b deletion. Abcb1a/b-deficient (Abcb1a/b(-/-)) mice displayed severe systolic dysfunction along with cardiomyocyte death in late embryonic and neonatal periods and early postnatal development. Furthermore, significantly higher expression levels of glucose transporters Glut1, Glut3, and Glut4, as well as phosphorylated hexokinase 2 (p-HK2), were observed in Abcb1a/b(-/-) hearts compared with those in wild-type mice, consistent with augmented glucose metabolism. On the other hand, no alternations were detected in lysosomal function or the morphology of the endo-lysosomes, autophagy, or apoptosis in Abcb1a/b(-/-) cardiomyocytes. In addition, a significant amount of fibrosis and increased levels of transforming growth factor-beta1 were noted in the myocardium of neonatal Abcb1a/b(-/-) mice. Expression of proinflammatory and fibrosis-related genes such as tumor necrosis factor alpha, interleukin 1 3e33713323


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